![]() Retin-A, aka tretinoin, has been clinically shown to increase cell turnover and stimulate collagen growth, encouraging fresh new skin with a more even tone and smoother texture.Tyrosinase is the enzyme that catalyzes the production of melanin, so inhibiting the activation of tyrosinase reduces the amount of melanin synthesized and carried to the superficial layers of the skin. ![]() Sacha Obaid, a plastic surgeon in Southlake, Texas. “The Cosmelan peel penetrates deep into the skin, to decrease the natural production of the tyrosinase enzyme,” says Dr. Cosmelan 2’s active ingredients are titanium dioxide, kojic acid, phytic acid, and ascorbic acid. Active ingredients in Cosmelan 1 include azelaic acid, kojic acid, phytic acid, ascorbic acid, arbutin, and titanium dioxide. Both the peel (Cosmelan 1) and cream (Cosmelan 2) contain ingredients that suppress melanin production.
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